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In addition, the fibroblasts release extracellular components which initiate the formation of collagen fibers that will serve as scaffolding. The initial vasoconstriction is followed by a vasodilation, which allows an influx of a variety of inflammatory cells which release several types of mediators and cytokines to promote thrombosis, angiogenesis, and re-epithelialization. The cascade of initial vasoconstriction of blood vessels and platelet aggregation play a key role in stopping the loss of blood. The delivery methodology (direct application, incorporated in fibrous membranes and hydrogels) is also presented and discussed. The challenges in the use of honey for wound healing are also covered and discussed. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can influence the healing properties, also highlighting promising results in in vitro and in vivo trials. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflammatory, and antimicrobial potential.

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